PJ-34
- Product Name
- PJ-34
- CAS No.
- 344458-19-1
- Chemical Name
- PJ-34
- Synonyms
- PJ-34;CS-856;PJ34(free base);PJ34;PJ-34;PJ 34;PJ34 PJ-34 A3729 A-3729;2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase
- CBNumber
- CB3434387
- Molecular Formula
- C17H17N3O2
- Formula Weight
- 295.34
- MOL File
- Mol file
PJ-34 Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 045156
- Product name
- PJ-34
- Packaging
- 1mg
- Price
- $282
- Updated
- 2021/12/16
- Product number
- A3729
- Product name
- PJ34
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-1463
- Product name
- PJ34
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-1463
- Product name
- PJ34
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CS-1463
- Product name
- PJ34
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $372
- Updated
- 2021/12/16
PJ-34 Chemical Properties,Usage,Production
Definition
ChEBI: PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, an antiatherosclerotic agent, a cardioprotective agent, an anti-inflammatory agent and a neuroprotective agent. It is a member of phenanthridines, a secondary carboxamide and a tertiary amino compound. It is a conjugate base of a PJ34(1+).
Enzyme inhibitor
This PARP inhibitor (FWfree-base = 295.34 g/mol; FWhydrochloride = 331.80 g/mol), systematically named N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)- N,N-dimethylacetamide and known for its activity in neuroprotection under stress conditions, exclusively eradicates multi-centrosomal human mammary, colon, lung, pancreas, ovarian cancer cells, by acting as an extracentrosome extracentrosome( s) de-clustering agent in mitosis. When applied at 20-30 μM, PJ-34 caused G2/M-arrest and a massive cell death Normal human proliferating endothelial, epithelial and mesenchymal cells were unaffected. PJ-34’s cytotoxicity on cancer cells is not attributable to PARP inhibition alone. PJ-34 was originally designed to protect neuronal cells in the central nervous system from cell death evoked by high activity of PARP-1 in response to DNA damage caused by brain injury, stroke or inflammation. Targets: extra-centrosome de-clustering; polyADP-ribose polymerase-1, EC50 = 20 nM